The concept of the show revolves around a family of dogs named the Doggies and their two roomates the Pussycat Brothers living in the town of New Bark City with "colorful neighbors" and other animals such as Ricky Mouse, Mr. Badger, Lamaly Bunny, Stacie Macks, Mr. Goat, TBD, TBD and TBD.
In a similar way to The Looney Tunes Show, the series features other segments which wrap around the main plot. These consist of:
- Blue Blaze - The many adventures of a superhero meerkat who is a parody of various action-adventure characters, most notably Collin the Speedy Boy.
- Jillian's Corner - a segment featuring Jilian showing different way to make art.
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- George Doggie (voiced by Billy West) - one of the two protagonists of the show, being Linda's husband and the patriarch of the family. He is a Bugs Bunny/Woody Woodpecker-esque trickster (coincidentally, his voice actor already voiced both), despite also being greedy and short-tempered like Fred Flintstone and Daffy Duck, coming with various schemes to fool his rivals or to get money, despite still being kind-hearted to his family and friends.
- Linda Doggie (voiced by Grey DeLisle) - one of the two protagonists of the show, being George's wife and the matriarch of the family, serving as the voice of the reason for George's crazy schemes and antics.
- Tyler Doggie (voiced by Charlie Adler) - the 17-year-old and eldest child of the Doggie children. He is depicted as a bossy, short-tempered and cynical teenager who is condescending towards his younger siblings. Despite this, he cares deeply about his family.
- Karen Doggie (voiced by Tara Strong) - the first middle child of the Doggie children. She is athletic and likes to play sports such as basketball, baseball, soccer, badminton, tennis, football, etc.
- Robbie Doggie (voiced by Jeff Bergman) - the second middle child of the Doggie children. He is depicted to be the most intelligent of the family and studies math and science. He is seen mostly helping Tyler with his problems on babysitting, giving him advice on how to date girls, and how to get his driver's license without failing his driving test.
- Jillian Doggie (voiced by Tress MacNeille) - the third middle child of the Doggie children. She is artistic and likes to draw and paint pictures, make 3D models out of modeling clay, and likes exhibiting things in various different types of art such as realism, impressionism, renaissance, modern, surrealism, etc.
- Kevin Doggie (voiced by Rob Paulsen) - Wendy's twin brother. (reserved for GrishamAnimationStudios102)
- Wendy Doggie (voiced by Cree Summer) - Kevin's twin sister. (reserved for GrishamAnimationStudios102)
- Joe Doggie (voiced by Bob Bergen) - (reserved for GrishamAnimationStudios102)
- Melissa Doggie (voiced by Nancy Cartwright) - the 6-year-old and youngest child of the Doggie children. She is a spoiled brat with a big ego and is very greedy and troublemaker.
- Steven and Sarah Doggie (voiced by Jeff Bennett and Kath Soucie, respectively) - two of the Doggies' neighbors. Steven is George's older brother, while Sarah is his wife.
- Sam and Bobo Pussycat (voiced by Corey Burton and Bill Farmer, respectively) - two cat brothers who live with the Doggies. Sam appears to be a selfish, devious, cranky, cruel and ridiculed character, but kind-hearted, while Bobo is clumsy and idiotic, but somewhat smart, aspiring to be a stand-up comedian and has skills to impersonate celebrities and cartoon voices.
- Ricky Mouse (voiced by Tom Kenny) - a mouse who lives at a hole on the Doggies' house who is commonly chased by the Pussycats, ending up to outsmart them.
- Frumpy (voiced by John DiMaggio) - George's pet rhea and best friend.
- Mr. Crocodile (also voiced by Jeff Bergman) - George's short-tempered boss.
- Mr. Badger (voiced by Maurice LaMarche) - one of the Doggies' neighbors. He is a liar, a thief and a cheater, amongst other things. He assumes the role of an antagonist when Kevin and Wendy anger him, but he always recives consequences for that.
- Lamaly Bunny (also voiced by Tress MacNeille) - a rabbit who is the Doggies' unlucky neighbor.
- Nina Poodle (voiced by Hynden Walch) - Tyler's girlfriend.
- Stacie Macks (voiced by Kristen Wiig) - a cat who has a crush on Sam, commonly stalking him, despite he doesn't have feelings for her.
- Dolores Gomez (voiced by Linda Cardellini) - Bobo's love interest. Like him, she's also interested on comedy and finds him cute and funny.
- Mr. Goat (also voiced by Charlie Adler) - a crazy goat who commonly annoys the Doggies with his various disguises.
- Ronnie Mouse (voiced by Bill Fagerbakke) - Ricky's dim-witted cousin.
- Barkwig Von Canine (also voiced by Rob Paulsen) - a German-accented professor who invents gadgets and machines. In one episode, he helps to turn Bobo back into his right age by creating an antidote to the one that resulted to turn him into a baby.
- Melvin the Psychologist (also voiced by Jeff Bergman) - the Doggies' psychologist. He's normally seen giving advices to Linda when she tries to get George out of trouble.
- George Doggie, Sr. and Grace Doggie (also voiced by Billy West and Grey DeLisle, respectively) - George's parents.
- Louis Doggett and Lacey Doggett (voiced by Jason Alexander and Kath Soucie, respectively) - Linda's parents.
- Mayor Lion (also voiced by Tom Kenny) - the excentric and flamboyant Mayor of New Bark City.
- Lapin Deer (also voiced by Grey DeLisle) - an female deer who is the local newscaster for WDOG-TV.
- Austin Meerkatowski/Blue Blaze (also voiced by Billy West) - a meerkat superhero who is a parody of various action-adventure characters, most notably Collin the Speedy Boy. He appears in his own segments.
- Alyson Marshall/Magical Star (also voiced by Hynden Walch) - a cartoon television character who is a spoof of magical girls like Sailor Moon and Magical DoReMi and Jillian's idol.
- Roger Pussycat (also voiced by Maurice LaMarche) - a retired aged British-accented comedian who is Sam and Bobo's grandfather, teaching the latter about how to be a good comedian, and a former star star on a hit TV show. His appearance, voice and mannerisms is based on British comedian Ricky Gervais.
- Lionald Truon (also voiced by Maurice LaMarche) - the President of the United States. He is a caricature of Donald Trump.
- Erim Evilman (also voiced by Tom Kenny) - a bat and arch enemy of Blue Blaze. He also appears in a few episodes of The Chronicles of Collin the Speedy Boy.
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|Voice actor||Character||Species||Voice based on||Notes|
|Billy West||George Doggie||Dog||Philip J. Fry from Futurama||Slighty deeper like Fry's time-duplicate Lars Fillmore from Bender's Big Game.|
|George Doggie, Sr.||Richard Nixon|
|Austin Meerkatowski/Blue Blaze||Meerkat||Doug Funnie from Nickelodeon's Doug||The character's secret identity speaks with a gruffier and deeper voice.|
|Grey DeLisle||Linda Doggie||Dog|
|Corey Burton||Sam Pussycat||Cat|
|Bill Farmer||Bobo Pussycat||Secret Squirrel from Harvey Birdman, Attorney at Law|
|Charlie Adler||Tyler Doggie||Dog||Chicken from Cow and Chicken|
|Mr. Goat||Goat||The Red Guy from Cow and Chicken and I Am Weasel||The character speaks with a British accent.|
|Jeff Bergman||Robbie Doggie||Dog|
|Mr. Crocodile||Crocodile||Mr. Spacely from The Jetsons|
|Melvin the Psychologist||Bear||Yogi Bear|
|Rob Paulsen||Kevin Doggie||Dog|
|Barkwig Von Canine||Dr. Scratchansniff from Animaniacs||The character speaks with a German accent.|
|Bob Bergen||Joe Doggie||Bucky the Squirrel from The Emperor's New Groove|
|Jeff Bennett||Steven Doggie||Dexter's father from Dexter's Laboratory|
|Kath Soucie||Sarah Doggie||Dexter's mother from Dexter's Laboratory|
|Tara Strong||Karen Doggie||Timmy Turner from The Fairly OddParents||Slighty higher-pitched to sound more like a girl.|
|Tress MacNeille||Jillian Doggie||Dot Warner from Animaniacs|
|Cree Summer||Wendy Doggie||Dog||Penny from Inspector Gadget|
|Nancy Cartwright||Melissa Doggie||Bart Simpson from The Simpsons||Slighty higher-pitched to sound more like a girl.|
|Tom Kenny||Ricky Mouse||Mouse||SpongeBob SquarePants||Slighty higher-pitched with a lisp added.|
|Mayor Lion||Lion||The Mayor of Townsville from The Powerpuff Girls||Slighty deeper to sound more competent.|
|Erim Evilman||Bat||Starscream from Transformers Animated||The character speaks with a German accent.|
|John DiMaggio||Frumpy||Rhea||Jake the Dog from Adventure Time||The character speaks with a Southern accent.|
|Maurice LaMarche||Mr. Badger||Badger||Yosemite Sam from Looney Tunes|
|Roger Pussycat||Cat||Ricky Gervais|
|Lionald Truon||Lion||Donald Trump|
|Hynden Walch||Nina Poodle||Dog||Princess Bubblegum from Adventure Time||The character speaks with a Canadian accent.|
|Alyson Marshall/Magical Star||TBA||Koriand'r/Starfire from Teen Titans and Teen Titans Go!|
|Kristen Wiig||Stacie Macks||Cat||Lola Bunny from The Looney Tunes Show|
|Linda Cardellini||Dolores Gomez||CJ from Regular Show|
|Bill Fagerbakke||Ronnie Mouse||Mouse||Patrick Star from SpongeBob SquarePants||Slighty deeper to sound less retarded. The character speaks with a New Jersey accent.|
|Jason Alexander||Louis Doggett||Dog||Eric Duckman from Duckman|
In late 2017, Warner Bros. Animation began on planning on a new sitcom involving a family of dogs, two cat brothers and a mouse. Ricky Mouse was modeled after Herman the Mouse (from Paramount Pictures/Harvey Entertainment), and Sam & Bobo were modeled after the comedy duo Abbott and Costello.
Spike Brandt and Tony Cervone developed a new show, with Bob Camp as the character designer of the main characters. Ralph Bakshi and John Kricfalusi brought in their staff of writers, ultimately creating The Doggies. Many of their episodes are inspired by Ren and Stimpy, with a few inspired by Tiny Toons Adventures, Animaniacs and The Amazing World of Gumball.
Kyle A. Carroza was known for making wildy drawn expressions with bigger details.
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The episodes were written by Vincent Waller, Jim Gomez, Bill Wray, Richard Pursel, Bob Camp, Jack Pendarvis, Tom Minton, Sherri Stoner and Ralph Bakshi. Story editing was done by John Kricfalusi and Ralph Bakshi themselves, respectively.
The voice cast is directed by John Kricfalusi himself since the show tends to imitate Ren and Stimpy, but more family-friendly.
Animation for The Doggies is farmed over to Toon City Animation in the Phillipines. The animation tends to be very fluid with Disney-style animation for a TV cartoon.
- The series follows the style of various family-oriented animated sitcoms, mainly The Flintstones, The Jetsons and The Looney Tunes Show, as well as some live-action sitcoms like Disney/Jim Henson's Dinosaurs.
- The series commonly mocks family and friendship issues, relationships, pop culture and politics.
- Various brands were "animalified" for the show.
- One of the most notable examples is CBS (sister channel to The CW, who airs the WB Kids block), shown as the Canine Broadcasting System, which WDOG-TV is affiliated to.
- It is implied in various episodes that The Doggies is in the same universe as Looney Tunes, leading incorrectly to be considered as part of the franchise.
- Kevin and Wendy are mainly based on Gumball and Darwin Watterson.
- Mellisa Doggie is mainly based on Bart Simpson.
- Ricky Mouse and Sam and Bobo Pussycat are mainly based on Tom and Jerry and similar characters like Sylvester Pussycat and Speedy Gonzales, Herman and Katnip and Pixie, Dixie and Mr. Jinks.
- Joe Doggie is mainly based on Scaredy Smurf and similar characters like Wembley Fraggle.
- Mr. Goat is mainly based on The Red Guy and similar characters such as Mr. Hollywood, various evil scientists and Roger the Alien.
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- In Episode 4 Me? A Criminal?, Dick Dastardly and Muttley (from Wacky Races), Hector Con Carne and Boskov (from Evil Con Carne), Marvin the Martian (from Looney Tunes) and McWolf (from Droopy) are seen on the police lineup, with Muttley (vocal effects by Frank Welker) providing his famous laugh. Also, photos of weasel versions of Rocky and Mugsy (from Looney Tunes) are seen in the police's notebook.
- In the Episode 7 Road Trip, Looney Tunes characters Bugs Bunny and Lola Bunny (voiced by Jeff Bergman and Kath Soucie, respectively) make a cameo, asking the Doggies how to get to Pismo Beach after Bugs taking the wrong turn in Albuquerque.
- In the Episode 12 Doggies' Help, when Sam, Steven and Sarah are in a train station, Sam decides to see the station's map, only to seeing a graffiti saying Rigby Was Here! Rigby Rules! (a reference to Rigby from Regular Show) written over the map, much to his anger.